There’s a photograph I keep pinned above my desk. A woman in her seventies, headscarf knotted, laughing as she carries a crate of vegetables up a terraced hillside in rural Japan.
I keep it there because of a puzzle she represents — one that changed the direction of my company.
For decades, when researchers surveyed women in regions like hers about the menopausal transition, something kept not showing up: hot flashes and night sweats were reported far less often than among women in the West. Not zero. But strikingly, consistently less.
Same biology. Same transition. Very different nights.
No one can point to a single proven cause — genetics, culture, even how symptoms get reported may all play a part. But one detail kept drawing researchers back: the traditional diet in these regions is unusually rich in soy. And soy carries isoflavones — plant compounds shaped so similarly to estrogen that they can interact, weakly and selectively, with the body’s own estrogen receptors.
Hold that thought. Because the reason that photograph stopped me cold had nothing to do with Japan.